Biochem/physiol Actions

Mutation in the leucine rich repeat kinase 2 (LRRK2) gene causes familial Parkinson′s disease (PD) and sporadic PD. Mitochondrial dysfunction is observed as a result of LRRK2 gene variation.

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General description

Leucine rich repeat kinase 2 (LRRK2) is a large protein containing protein-protein interaction region enclosing two main domains for : central kinase and GTPase.

Immunogen

Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. ﹤30% identity with LRRK1.

Physical form

PBS pH 7.4, 50% glycerol, 0.1% sodium azide